T7 RNA Polymerase, low dsRNA

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Modified T7 RNA Polymerase for efficient synthesis of RNA, especially in mRNA synthesis. This version generates a lower level of dsRNA in IVT.



T7 RNA Polymerase, low dsRNA 50 U/µl  is used in In-vitro transcription to incorporate NTPs into the growing mRNA chain, especially in mRNA synthesis. It is an DNA-dependent RNA polymerase and synthesizes RNA in 5’→3′ direction from linear DNA containing the T7 promoter. Compared to the wild-type T7 RNA polymerase, this product generates much lower level of double-strand RNA (dsRNA) during the IVT process, which makes the mRNA less immunogenic. Either linearized plasmids or PCR products can be used as IVT templates.

This product comes with a 10x Transmission Buffer.

  • REF
  • Pack Size

  • 10308-20K
  • 100 µl/ 20 kU

  • 10308-200K
  • 1 ml/ 200 kU

  • 10308-2M
  • 10 ml/ 2 MU

In-vitro Transcription (IVT) of mRNA for synthesis of therapeutics and/ or vaccines.

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