402007

COT I Human DNA

COT I Human DNA

REF: 402007 - 402011

High-quality COT I Human DNA derived from male placental DNA and enriched for repetitive sequences (50–300 bp), optimized for precise hybridization and NGS applications.

Enhances specificity by reducing background noise and suppressing cross-hybridization, resulting in higher on-target read rates in genomic assays such as microarrays and in situ hybridization.

You need to login here before you can buy any products

excl. VAT

Description

High-Quality Human COT I DNA for Hybridization and NGS Applications
Premium-grade human COT I DNA derived exclusively from male placental genomic DNA. The proprietary production process is specifically optimized to enrich highly repetitive DNA elements, resulting in a consistent fragment size distribution of 50–300 base pairs. This precise composition gives BIORON`s COT I Human DNA unique performance characteristics, making it an essential reagent for a wide range of molecular biology and genomic applications.

Optimized for Hybridization Assays
COT I Human DNA is widely used as a blocking agent to suppress cross-hybridization to repetitive human DNA sequences. This ensures highly specific probe binding to chromosomal target regions, improving accuracy and signal clarity.

Enhanced Performance in Next-Generation Sequencing (NGS)
In NGS workflows, COT I Human DNA functions as an effective blocking reagent to reduce non-specific hybridization events. This leads to significantly improved on-target read rates and overall sequencing efficiency, making it a valuable component in high-throughput genomic studies.

Consistent Quality and Manufacturing Excellence
Manufactured in Germany under stringent quality standards, COT I Human DNA is produced from carefully selected male human placental DNA. The DNA is fragmented and processed to isolate the COT fraction, which is enriched in fast-annealing repetitive sequences. Continuous process optimization ensures a reproducible and uniform fragment size distribution, delivering reliable performance across batches.

Flexible Product Options
COT I Human DNA is available from BIORON specified according to your customer requirements.
For fragment sizes in a range of > 10 kb BIORON offers bulk quantities of Human Placenta DNA (REF 401022) on request.
More information or a quote are available on request, please contact us directly.

 

Applications

  • Filter/ Microarray hybridization assays
  • In-situ hybridization (e.g. FISH)
  • Single-copy-gene hybridization
  • Reduction of cross hybridization

Key Features

  • High enrichment of repetitive human DNA sequences
  • Balanced proportion of Y-chromosomal sequences
  • Reliable fragment size distribution (50–300 bp)
  • Improved specificity in hybridization assays
  • Enhanced on-target rates in NGS workflows
  • Customizable formats and bulk supply options


    Related products